This issue of Critical Care Clinics, guest edited by Dr. Janice L. Zimmerman, focuses on Toxicology. This is one of four issues each year selected by the series consulting editor, Dr. John Kellum. Articles in this issue include, but are not limited to: Pharmacokinetic and pharmacodynamic principles for toxicology, Use of extracorporeal techniques in poisonings, Drugs of Abuse, Cardiovascular Drug Toxicity, Anticoagulant and Anti-platelet Drug Toxicity and Psychotropic Agents.